| Item Type | Name |
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Concept
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beta-Galactosidase
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Concept
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Inhibins
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Concept
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Protein Subunits
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Concept
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Transforming Growth Factor beta
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Concept
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Amyloid beta-Protein Precursor
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Concept
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beta Catenin
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Concept
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Integrin beta1
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Concept
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HLA-DP beta-Chains
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Academic Article
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A novel regulatory mechanism for trimeric GTP-binding proteins in the membrane and secretory granule fractions of human and rodent beta cells.
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Academic Article
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Specific co-ordinated regulation of PC3 and PC2 gene expression with that of preproinsulin in insulin-producing beta TC3 cells.
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Academic Article
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Acute stimulation with long chain acyl-CoA enhances exocytosis in insulin-secreting cells (HIT T-15 and NMRI beta-cells).
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Academic Article
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Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.
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Academic Article
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A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth.
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Academic Article
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Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1).
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Academic Article
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Synaptotagmin III isoform is compartmentalized in pancreatic beta-cells and has a functional role in exocytosis.
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Academic Article
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Glycerol-stimulated proinsulin biosynthesis in isolated pancreatic rat islets via adenoviral-induced expression of glycerol kinase is mediated via mitochondrial metabolism.
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Academic Article
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Cysteine string protein (CSP) is an insulin secretory granule-associated protein regulating beta-cell exocytosis.
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Academic Article
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Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation.
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Academic Article
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Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells.
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Academic Article
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Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling.
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Academic Article
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Pancreatic beta-cell growth and survival--a role in obesity-linked type 2 diabetes?
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Academic Article
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Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation.
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Academic Article
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Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis.
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Academic Article
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Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1).
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Academic Article
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Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells.
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Academic Article
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Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide.
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Academic Article
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Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin.
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Academic Article
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Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells.
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Academic Article
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Fluorescent cargo proteins in pancreatic beta-cells: design determines secretion kinetics at exocytosis.
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Academic Article
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Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells.
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Academic Article
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Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B.
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Academic Article
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Type 2 diabetes-a matter of beta-cell life and death?
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Academic Article
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10th EASD/JDRF Oxford Workshop. What is a beta-cell and can we improve it?
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Academic Article
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Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells.
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Academic Article
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Impact of defined matrix interactions on insulin production by cultured human beta-cells: effect on insulin content, secretion, and gene transcription.
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Academic Article
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Inositol (1,4,5)-trisphosphate dynamics and intracellular calcium oscillations in pancreatic beta-cells.
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Academic Article
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Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?
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Academic Article
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Decreasing IRS-2 expression in pancreatic beta-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression.
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Academic Article
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Beta-cell regeneration: epithelial mesenchymal transition pre-EMTpted by lineage tracing?
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Academic Article
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Regulated autophagy controls hormone content in secretory-deficient pancreatic endocrine beta-cells.
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Academic Article
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Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells.
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Academic Article
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Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element.
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Academic Article
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Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.
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Academic Article
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Exendin 4 controls insulin production in rat islet beta cells predominantly by potentiation of glucose-stimulated proinsulin biosynthesis at the translational level.
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Academic Article
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Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3ß independent of JNK activation.
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Academic Article
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Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells.
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Academic Article
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AMP-activated protein kinase attenuates nitric oxide-induced beta-cell death.
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Academic Article
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Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass.
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Academic Article
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Degradation of islet amyloid polypeptide by neprilysin.
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Academic Article
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Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases.
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Academic Article
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What beta-cell defect could lead to hyperproinsulinemia in NIDDM? Some clues from recent advances made in understanding the proinsulin-processing mechanism.
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Academic Article
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PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells.
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Academic Article
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Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1.
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Academic Article
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Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation.
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Academic Article
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Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).
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Academic Article
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IRS-3 inhibits IRS-2-mediated signaling in pancreatic beta-cells.
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Academic Article
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Glucagon-like peptide-1 prevents beta cell glucolipotoxicity.
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Academic Article
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Intragranular targeting of syncollin, but not a syncollinGFP chimera, inhibits regulated insulin exocytosis in pancreatic beta-cells.
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Academic Article
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Glycogen synthase kinase 3 beta mediates high glucose-induced ubiquitination and proteasome degradation of insulin receptor substrate 1.
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Academic Article
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Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways.
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Academic Article
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IGF-I and GH post-receptor signaling mechanisms for pancreatic beta-cell replication.
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Academic Article
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Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells.
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Academic Article
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ß1 integrin is a crucial regulator of pancreatic ß-cell expansion.
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Academic Article
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Free Fatty Acid-Induced Inhibition of Glucose and Insulin-Like Growth Factor I-Induced Deoxyribonucleic Acid Synthesis in the Pancreatic ß-Cell Line INS-1* * This work was supported by grants from the NIH (GK-55267), the Juvenile Diabetes Foundation International, the German Research Society, and BetaGene, Inc.
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Academic Article
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Codependence of Bone Morphogenetic Protein Receptor 2 and Transforming Growth Factor-ß in Elastic Fiber Assembly and Its Perturbation in Pulmonary Arterial Hypertension.
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Academic Article
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BMPR-II deficiency elicits pro-proliferative and anti-apoptotic responses through the activation of TGFß-TAK1-MAPK pathways in PAH.
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Academic Article
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Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1.
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Academic Article
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Identification of rare sequence variation underlying heritable pulmonary arterial hypertension.
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Academic Article
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Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis.
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Academic Article
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Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood.
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Concept
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Glycogen Synthase Kinase 3 beta
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Concept
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Protein Kinase C beta
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Grant
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Mitogenic Signal Transduction in Pancreatic Beta-Cells
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Grant
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Metabolic Control of Insulin Exocytosis
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Grant
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Western Region Islet Study Group
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Academic Article
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Serum and Pulmonary Expression Profiles of the Activin Signaling System in Pulmonary Arterial Hypertension.
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